Programming mammalian gene expression with the antibiotic simocyclinone D8 and the flavonoid luteolin

Similar to one of my previous publications in which I programmed gene expression in human cells with caffeine, here we used the antibiotic simocyclinone D8 and the flavonoid luteolin to activate gene expression when we wanted to. Making use of bacterial transcription factors, which naturally sense these molecules, we could build these novel gene switches and combine them in simple logic gates. This work, published in the American Institute of Chemical Engineers Journal (AIChE J), further extends the toolkit of synthetic biology (especially for mammalian synthetic biology) and contributes towards important areas such as biocomputing.

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